Open Access
Review

The canonical Wnt-beta-catenin pathway in development and chemotherapy of osteosarcoma

Chengjun Li1,Xin Shi1,Guangxin Zhou1,Xiaozhou Liu1,Sujia Wu1,Jianning Zhao1,*
1
Jinling Hospital, Dept Orthopedics, Nanjing Univ, Sch Med ,Nanjing 210002, Peoples R China
DOI: 10.2741/4187 Volume 18 Issue 4, pp.1384-1391
Published: 01 June 2013
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
*Corresponding Author(s):  
Jianning Zhao
E-mail:  
zhaojianning0207@yeah.net
Abstract

The canonical Wnt-beta -catenin signaling pathway is a key component of normal skeletal development and disease. Alterations within this signaling pathway have been described in human and canine osteosarcoma (OS); however, debate exists as to whether or not alterations in this pathway contribute to OS development in humans. In metastatic OS, the Wnt-βcatenin pathway promotes the invasion and migration of OS cells and β-catenin acts as a biological marker of OS with the potential to metastasize to the lung. The participation of the Wnt-β-catenin pathway in OS development and metastasis is regulated by several factors, including hormones and alkaline phosphatase (ALP). This pathway is also involved in the resistance of OS to chemotherapy, especially in resistance to all three drugs used in standard chemotherapy, i.e. doxorubicin, cisplatin and methotrexate (MTX). In this review, we will summarize recent findings regarding the Wnt-β-catenin pathway in OS development and chemotherapy.

Key words

Wnt-beta-catenin; Osteosarcoma; Development; Chemotherapy, Review

Share and Cite
Chengjun Li, Xin Shi, Guangxin Zhou, Xiaozhou Liu, Sujia Wu, Jianning Zhao. The canonical Wnt-beta-catenin pathway in development and chemotherapy of osteosarcoma. Frontiers in Bioscience-Landmark. 2013. 18(4); 1384-1391.