Open Access

Expression and significance of aquaporins during pregnancy

Ying Hua1,Wenxiao Jiang1,Wenwen Zhang1,Qi Shen1,Miaomiao Chen1,Xueqiong Zhu1,*
Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China
DOI: 10.2741/4186 Volume 18 Issue 4, pp.1373-1383
Published: 01 June 2013
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
*Corresponding Author(s):  
Xueqiong Zhu

Outcome of a pregnancy is dependent on highquality ovulation, successful fertilization, normal embryonic and fetal development, and homeostasis of amniotic fluid. Throughout pregnancy, aquaporins are expressed in the placenta, uterus, adnexa, brain, urinary system, and the lacrimal gland. The regional and temporal regulation of aquaporins play important roles in normal pregnancy, fetal growth, and homeostasis of amniotic fluid volume, and water handling in other organs. The pregnant phenotypes of aquaporin-knockout mice provide direct evidence that aquaporins deficiency results in adverse outcome of pregnancy. Therefore, screening for modulation of aquaporin in abnormal pregnancy becomes desirable. Alteration of aquaporins is seen in preeclampsia, abnormal amniotic fluid volume, chorioamnionitis, and maternal under-nourished pregnancy. Although the functional importance of aquaporins remains to be elucidated, its expression and regulation in abnormal pregnancy suggests potential therapeutic strategies for the treatment of abnormal pregnancy.

Key words

Aquaporins; Pregnancy; Placenta, Review

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Ying Hua, Wenxiao Jiang, Wenwen Zhang, Qi Shen, Miaomiao Chen, Xueqiong Zhu. Expression and significance of aquaporins during pregnancy. Frontiers in Bioscience-Landmark. 2013. 18(4); 1373-1383.