Open Access

Diagnosis, management, and prevention of prosthetic joint infections

Ji-Min Yin1,Zhong-Tang Liu1,Shi-Chang Zhao1,Yan-Jie Guo1,*
Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, No.600 Yishan Road, Shanghai 200233, China
DOI: 10.2741/4184 Volume 18 Issue 4, pp.1349-1357
Published: 01 June 2013
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
*Corresponding Author(s):  
Yan-Jie Guo

As the number of joint prosthesis replacements worldwide increases exponentially, prosthetic joint infection (PJI), associated with prosthetic implants, has become a devastating complication associated with high morbidity and substantial cost. Patients who develop PJIs typically require extended hospitalization, additional surgical procedures, and long courses of parenteral antimicrobials. Defining the diagnostic criteria is complicated by patient heterogeneity. No single routinely used clinical test has been shown to achieve the ideal sensitivity, specificity, and accuracy for the diagnosis of PJI. Goals of treatment are to eradicate infection, prevent recurrence, and preserve mechanical joint function. Meanwhile, preventive strategies should be used in a timely and appropriate fashion. The present review will discuss the diagnosis, management, and prevention of PJI.

Key words

Prosthetic Joint Infections, Diagnosis, Management, Prevention , Review

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Ji-Min Yin, Zhong-Tang Liu, Shi-Chang Zhao, Yan-Jie Guo. Diagnosis, management, and prevention of prosthetic joint infections. Frontiers in Bioscience-Landmark. 2013. 18(4); 1349-1357.