Open Access

Effects and mechanisms of mechanical stress on secondary fracture healing

Xingang Yu1,*,Yanjie Guo1,Qinglin Kang1,Congfeng Luo1
Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, No.600 Yishan Road, Shanghai 200233, China
DOI: 10.2741/4183 Volume 18 Issue 4, pp.1344-1348
Published: 01 June 2013
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
*Corresponding Author(s):  
Xingang Yu

Fracture healing is an extremely complex biological reconstruction process, affected by age, hormones, blood supply, degree of injury, mechanical load and many other factors, among which, mechanical stimuli is one of the most important. Bone tissue has a good adaptability to mechanical stress, as biomechanical studies have shown that the local mechanical environment of the fracture site plays a regulatory role in the process of fracture healing (1,2). The present article reviews the mechanical mechanisms and effects of mechanical stress on fracture healing.

Key words

Mechanical Stress; Secondary Fracture Healing; Mechanisms; Review

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Xingang Yu, Yanjie Guo, Qinglin Kang, Congfeng Luo. Effects and mechanisms of mechanical stress on secondary fracture healing. Frontiers in Bioscience-Landmark. 2013. 18(4); 1344-1348.