Open Access

Inhibition of ErbB receptors, Hedgehog and NF-kappaB signaling by polyphenols in cancer

Monica Benvenuto1,Massimo Fantini1,Laura Masuelli2,Enrico De Smaele2,Francesca Zazzeroni3,Ilaria Tresoldi1,Giorgio Calabrese4,Fabio Galvano5,Andrea Modesti1,Roberto Bei1,*
Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy
Department of Experimental Medicine, University of Rome Sapienza, Rome, Italy
Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
Department of Biology, Piemonte Orientale University, Alessandria, Italy
Department of Drug Sciences, Section of Biochemistry, University of Catania, Catania, Italy
DOI: 10.2741/4180 Volume 18 Issue 4, pp.1290-1310
Published: 01 June 2013
(This article belongs to the Special Issue Dietary approaches to prevent chronic-degenerative diseases)
*Corresponding Author(s):  
Roberto Bei

Carcinogenesis is a multi-step process triggered by cumulative genetic alterations, which drive the progressive transformation of a normal cell into a cancer cell. Among the signal transduction pathways whose crosstalk plays an important role in neoplastic transformation are those mediated by ErbB receptors, NF-kappaB and the Hedgehog (HH)/glioma-associated oncogene (GLI) cascade. Polyphenols can be employed to inhibit the growth of cancer cells due to their ability to modulate the activity of multiple targets involved in carcinogenesis through simultaneous direct interaction or modulation of gene expression. This review will describe the cross-talk between ErbB receptors, NF-kappaB and the Hedgehog (HH)/glioma-associated oncogene (GLI) signaling pathways and the potential role of polyphenols in inhibiting this dialogue and the growth of cancer cells.

Key words

Polyphenols, ErbB receptor, Hedgehog, NFkappaB, Cancer, Review

Share and Cite
Monica Benvenuto, Massimo Fantini, Laura Masuelli, Enrico De Smaele, Francesca Zazzeroni, Ilaria Tresoldi, Giorgio Calabrese, Fabio Galvano, Andrea Modesti, Roberto Bei. Inhibition of ErbB receptors, Hedgehog and NF-kappaB signaling by polyphenols in cancer. Frontiers in Bioscience-Landmark. 2013. 18(4); 1290-1310.