Open Access

Materials for the onset. A story of necessity and chance

Raffaele Saladino1,Giorgia Botta2,Samanta Pino3,Giovanna Costanzo4,Ernesto Di Mauro5,*
Dipartimento di Agrobiologia ed Agrochimica , Universita della Tuscia, Via San Camillo De Lellis, 01100 Viterbo, Italy
Dipartimento di Scienze Ecologiche e Biologiche, University of Tuscia, Via S. Camillo de Lellis, 01100 Viterbo, Italy
Dipartimento di Biologia e Biotecnologie, Charles Darwin, “Sapienza” Universita di Roma, P.leAldo Moro, 5, Rome 00185, Italy
Istituto di Biologia e e Patologia Molecolari, CNR, P.le Aldo Moro, 5, Rome 00185, Italy
Istituto Pasteur “Fondazione Cenci-Bolognetti”, Italy
DOI: 10.2741/4179 Volume 18 Issue 4, pp.1275-1289
Published: 01 June 2013
(This article belongs to the Special Issue The transition from constraint to regulation at the origin of life)
*Corresponding Author(s):  
Ernesto Di Mauro

We review the reactions that take place in the HCN/NH2COH/catalysts system. In a vision of origin-oflife as emergence of new properties in complexity, the effectiveness of HCN/NH2COH chemistry is so robust and variegate to look unreasonable. In a logic close to Occamian simplicity, this chemistry embodies necessity. The evolution of the necessary fruits of this chemistry towards organismic level entails Darwinism. The role of chance enters into the process as an answer to evolving environments.

Key words

Non-definition of life, Origin Of Coordinated Reactions, Formamide, Metabolism, RNA, Review

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Raffaele Saladino, Giorgia Botta, Samanta Pino, Giovanna Costanzo, Ernesto Di Mauro. Materials for the onset. A story of necessity and chance. Frontiers in Bioscience-Landmark. 2013. 18(4); 1275-1289.