Open Access

Hepatitis B virus X protein in the proliferation of hepatocellular carcinoma cells

Peng Gong1,*,Xianbin Zhang1,Jian Zhang1,Jing Zhang1,Haifeng Luo1,Zhongyu Wang1
Department of Hepatobiliary Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian, China
DOI: 10.2741/4177 Volume 18 Issue 4, pp.1256-1265
Published: 01 June 2013
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
*Corresponding Author(s):  
Peng Gong

Hepatocellular carcinoma (HCC) is one of the most common and deadly malignant neoplasms worldwide. Chronic hepatitis B virus (HBV) infection is closely associated with the occurrence of HCC. The HBV genome encodes a ubiquitous transactivator, termed the HBV X protein (HBx), that is essential for HBV replication in vivo. HBx is involved in multiple steps of carcinoma development. Even in the preneoplastic stage, HBx acts as a tumor promoter. HBx participates in several mechanisms that have been linked to cell proliferation, including gene transcription, cell cycle regulation, and several signaling pathways. Moreover, HBx mutants, especially those with mutations in the COOH-terminal end, have been implicated in hepatocarcinogenesis. Therefore, therapeutic strategies targeting HBx could be effective at multiple stages of HCC development, even as early as the preneoplastic stage.

Key words

Hepatocellular Carcinoma, Hepatitis B virus X protein, proliferation, Review

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Peng Gong, Xianbin Zhang, Jian Zhang, Jing Zhang, Haifeng Luo, Zhongyu Wang. Hepatitis B virus X protein in the proliferation of hepatocellular carcinoma cells. Frontiers in Bioscience-Landmark. 2013. 18(4); 1256-1265.