Open Access
Review

The role of TLR4 in the pathogenesis of indirect acute lung injury

Rong Hu1,Hui Xu1,Hong Jiang1,*,Ying Zhang1,Yu Sun1
1
Department of Anesthetics, Shanghai Ninth People’s Hospital affiliated with Shanghai Jiao Tong University, School of Medicine, N.O. 639, Zhizaoju Road, Shanghai 200011, China
DOI: 10.2741/4176 Volume 18 Issue 4, pp.1244-1255
Published: 01 June 2013
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
*Corresponding Author(s):  
Hong Jiang
E-mail:  
dr_jianghong@yeah.net
Abstract

Indirect acute lung injury (IALI) manifests as rapid-onset respiratory failure following secondary clinical events to the parenchyma or lung vasculature, such as hemorrhage shock, extra-pulmonary sepsis, trauma, ischemia-reperfusion, and burn injury. Accumulating evidence demonstrates the pivotal role of pattern recognition receptors (PRRs) in the innate immune system of lung diseases. Toll like receptor 4 (TLR4), one of the well characterized PRRs, recognizes not only the lipopolysaccharide (LPS) of Gram-negative bacteria, but also the endogenous ligands in IALI. In this review, we summarize a variety of reports concerning the role of TLR4 and IALI pathogenesis.

Key words

TLR4, IALI, LPS, Sepsis, Trauma Hemorrhage Shock, Ischemia-Reperfusion, Burn Injury, Review

Share and Cite
Rong Hu, Hui Xu, Hong Jiang, Ying Zhang, Yu Sun. The role of TLR4 in the pathogenesis of indirect acute lung injury. Frontiers in Bioscience-Landmark. 2013. 18(4); 1244-1255.