Open Access

Approaches on genetic polymorphism of Cryptococcus Species Complex

Meng Li1,Min Chen1,Weihua Pan1,*
Department of Dermatology, Shanghai Key Laboratory of Molecular Mycology & PLA Key Laboratory of Fungal Diseases, ChangZheng Hospital Second Military Medical University, Shanghai, China
DOI: 10.2741/4174 Volume 18 Issue 4, pp.1227-1236
Published: 01 June 2013
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
*Corresponding Author(s):  
Weihua Pan

The Cryptococcus species complex is the significant pathogenic fungi that result in over 1 million cases of cryptococcosis each year in the world. Proper strategy for genetic polymorphism study of the Cryptococcus species complex is crucial to unfold genetic population structure, spread profile and pathogenicity of these pathogenic yeasts worldwide. Currently, an array of approaches, including serotype, PCR fingerprinting, amplified fragment length polymorphisms (AFLP), analysis of DNA sequence, and matrix-assisted laser desorption/ionization time of flight mass spectrometry(MALDI-TOF MS) etc. improved our understanding of genetic diversity or phylogenetic of Cryptococcus species complex. This review synthesizes existing techniques of cryptococcal genetic polymorphism and raises issues that remain to be addressed.

Key words

Cryptococcus Species Complex; Genetic Diversity; Molecular Approach; Advance, Review

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Meng Li, Min Chen, Weihua Pan. Approaches on genetic polymorphism of Cryptococcus Species Complex. Frontiers in Bioscience-Landmark. 2013. 18(4); 1227-1236.