Open Access

Endothelial progenitor cells and atherosclerosis

Changwu Ruan1,*,Yan Shen1,Rui Chen1,Zhancheng Wang1,Jin Li1,Yun Jiang1
Department of Cardiology, the 8th Renmin hospital, Shanghai, No.8 Cao Bao Road,Shanghai, 200235, China
DOI: 10.2741/4172 Volume 18 Issue 4, pp.1194-1201
Published: 01 June 2013
*Corresponding Author(s):  
Changwu Ruan

Atherosclerosis is due to inflammation and endothelial dysfunction and damage caused by a variety of factors. Dysfunction of endothelial progenitor cells (EPCs) that differentiate into mature endothelial cell contributes to the development of atherosclerosis. Both the number and functionality of EPCs are regulated, particularly in vascular repair. Further elucidation of the role of EPCs in atherosclerosis could potentially enable the development of novel strategies for prevention and treatment of pathological changes in atherosclerosis.

Key words

Endothelial progenitor cells, PI3K, SDF1alfa, Review

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Changwu Ruan, Yan Shen, Rui Chen, Zhancheng Wang, Jin Li, Yun Jiang. Endothelial progenitor cells and atherosclerosis. Frontiers in Bioscience-Landmark. 2013. 18(4); 1194-1201.