Open Access
Review

Mitochondrial dysfunction-related genes in hepatocellular carcinoma

Weilin Wang1,Qiang Sun1,Zehui Wu1,Dongkai Zhou1,Jianfeng Wei1,Haiyang Xie1,2,Lin Zhou1,2,Shusen Zheng1,2,*
1
Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Key laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation, Hangzhou, 310003, Zhejiang Province, China
2
Department of General Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang Province, China
DOI: 10.2741/4169 Volume 18 Issue 3, pp.1141-1149
Published: 01 June 2013
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
*Corresponding Author(s):  
Shusen Zheng
E-mail:  
shusenzheng@yeah.net
Abstract

Mitochondria dysfunction is associated with apoptotic resistance and metabolism of tumor cells. Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor with multiple genetic aberrations. Certain gene mutations in mitochondria may lead to mitochondrial dysfunction. The p53 family plays a key role in the mitochondrial apoptosis pathway and acts as part of the molecular mechanisms underlying mitochondrial dysfunction in HCC. The novel genes found in the mitochondrial apoptosis signaling pathways, such as mfn2, play a role in the p53 network. In mitochondrial metabolism, expression of certain genes may be associated with apoptosis when they are involved in hepatocarcinogenesis. MicroRNAs have also been found to play a role in this process. Some genes may even exhibit multiple functions in the mitochondrial dysfunction of HCC. In HCC therapy, genes have also been found to influence the chemotherapeutic treatment by killing cells via the apoptosis pathway or autophagy. Investigation of mitochondrial dysfunction-related genes could potentially provide evidence for novel therapies that target HCC.

Key words

Hepatocellular Carcinoma, Mitochondrial Dysfunction, Gene, Review

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Weilin Wang, Qiang Sun, Zehui Wu, Dongkai Zhou, Jianfeng Wei, Haiyang Xie, Lin Zhou, Shusen Zheng. Mitochondrial dysfunction-related genes in hepatocellular carcinoma. Frontiers in Bioscience-Landmark. 2013. 18(3); 1141-1149.