Open Access

Creation of a suppressive microenvironment by macrophages and cancer-associated fibroblasts

Magdalena Dutsch-Wicherek1,*,Wojciech Kazmierczak1
Department of Gynecology, Obstetrics and Oncology, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Outpatient Unit of Otolaryngology Lukaszczyk Oncological Center in Bydgoszcz, Poland
Department of Otolaryngology and Oncological Laryngology with Subdivision of Audiology and Phoniatry Jurasz's University Hospital in Bydgoszcz", Department of Pathophisiology of Hearing and Balance System, Ludwik Rydygier's Collegium Medicum, Nicolaus Copernicus University in Bydgoszcz, Poland
DOI: 10.2741/4159 Volume 18 Issue 3, pp.1003-1016
Published: 01 June 2013
*Corresponding Author(s):  
Magdalena Dutsch-Wicherek

The cancer microenvironment makes up the stroma of the neoplasm and is the tissue that determines tumor growth, progression, and ability to initiate metastases. Because of the role that the cancer microenvironment plays in each stage of tumor development, knowledge about the interactions of the tumor with its microenvironment would seem to be of the utmost importance for developing new treatment strategies. The cancer microenvironment is created by the tissue surrounding the tumor cells and is composed of cells, extracellular matrix, and the proteins of the extracellular matrix. Although tumor cells are capable of penetrating the surrounding stroma, it is the tumor stroma that provides the necessary blood supply and growth factors for the tumor cells that condition tumor growth. In the present review we discuss the role of various cells like tumor-associated macrophages and cancer-associated fibroblasts, expressing RCAS1, B7-H4 molecules, and MT in creating the suppressive profile of the cancer microenvironment and in the cancer microenvironment remodeling that enables both local tumor spread and the creation of metastases.

Key words

Cancer, Neoplasms, Tumor, Microenvironment, Suppressive, Macophage, Fibroblast, Review

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Magdalena Dutsch-Wicherek, Wojciech Kazmierczak. Creation of a suppressive microenvironment by macrophages and cancer-associated fibroblasts. Frontiers in Bioscience-Landmark. 2013. 18(3); 1003-1016.