Open Access
Bone marrow mesenchymal stem cells in hepatocellular carcinoma
Peng Gong1,*,Yingxin Wang1,Jing Zhang1,Zhongyu Wang1
Department of Hepatobiliary Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian, China
DOI: 10.2741/4145 Volume 18 Issue 3, pp.811-819
Published: 01 June 2013
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
*Corresponding Author(s):  
Peng Gong

Bone marrow mesenchymal stem cells (BMSCs) are non-hematopoietic multipotent stem cells capable of differentiating into mature cells. Studies in animal models have indicated that hepatocellular carcinoma (HCC) may originate from genetically mutated BMSCs. Moreover, it has been shown that BMSCs are influenced by and can modulate their micro-environment via secreted cytokines that promote tumor initiation, growth, and homing to tumor sites. Based on these features, BMSCs have been recognized as a putative target of molecular therapies to treat and prevent HCC. In this review we discuss the role of human BMSCs in HCC pathogenesis and their therapeutic potential.

Key words

Bone marrow mesenchymal stem cells, hepatocellular carcinoma, vascular endothelial cell growth factor, Review

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Peng Gong, Yingxin Wang, Jing Zhang, Zhongyu Wang. Bone marrow mesenchymal stem cells in hepatocellular carcinoma. Frontiers in Bioscience-Landmark. 2013. 18(3); 811-819.