The miRNAs in the pathgenesis of osteosarcoma
Department of Orthopedics, Shaoxing People’s Hospital, Zhejiang 312000, China
Department of Orthopedics, The 306th Hospital of PLA, Beijing 100101, China
Department of Nephrology, Tongji Hospital of Tongji University, Shanghai 200065, China
Department of Orthopedics, Changhai Hospital of Second Military Medical University, Shanghai 200433, China
01 January 2013
Osteosarcoma is an aggressive sarcoma of the bone
characterized by a high level of genetic instability and
recurrent DNA deletions and amplifications. MicroRNAs
(miRNAs) are non-coding small RNAs, usually 18–25
nucleotides in length, which repress translation and cleave
mRNA by base-pairing to the 3 untranslated region of the
target genes. miRNAs have demonstrated far-reaching
effects on the cellular biology of development and cancer.
Their role in osteosarcomagenesis remains largely
unexplored. A number of reports have investigated the role
of microRNAs in osteosarcoma. This review summeizes the
recent research progress of miRNA in the osteosarcome.
miRNAs, siRNAs, mRNA, Review
Share and Cite
Wenqing Liang, Bo Gao, Peng Fu, Shuogui Xu, Yu Qian, Qingge Fu. The miRNAs in the pathgenesis of osteosarcoma. Frontiers in Bioscience-Landmark. 2013. 18(2); 788-794.