Open Access
The miRNAs in the pathgenesis of osteosarcoma
Wenqing Liang1,Bo Gao2,Peng Fu3,Shuogui Xu4,Yu Qian1,Qingge Fu4,*
Department of Orthopedics, Shaoxing People’s Hospital, Zhejiang 312000, China
Department of Orthopedics, The 306th Hospital of PLA, Beijing 100101, China
Department of Nephrology, Tongji Hospital of Tongji University, Shanghai 200065, China
Department of Orthopedics, Changhai Hospital of Second Military Medical University, Shanghai 200433, China
DOI: 10.2741/4142 Volume 18 Issue 2, pp.788-794
Published: 01 January 2013
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
*Corresponding Author(s):  
Qingge Fu

Osteosarcoma is an aggressive sarcoma of the bone characterized by a high level of genetic instability and recurrent DNA deletions and amplifications. MicroRNAs (miRNAs) are non-coding small RNAs, usually 18–25 nucleotides in length, which repress translation and cleave mRNA by base-pairing to the 3 untranslated region of the target genes. miRNAs have demonstrated far-reaching effects on the cellular biology of development and cancer. Their role in osteosarcomagenesis remains largely unexplored. A number of reports have investigated the role of microRNAs in osteosarcoma. This review summeizes the recent research progress of miRNA in the osteosarcome.

Key words

miRNAs, siRNAs, mRNA, Review

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Wenqing Liang, Bo Gao, Peng Fu, Shuogui Xu, Yu Qian, Qingge Fu. The miRNAs in the pathgenesis of osteosarcoma. Frontiers in Bioscience-Landmark. 2013. 18(2); 788-794.