Open Access

Tendon-derived stem cells as a new cell source for tendon tissue engineering

Qiang Zhang1, Biao Cheng1,*
Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China
DOI: 10.2741/4138 Volume 18 Issue 2, pp.756-764
Published: 01 January 2013
(This article belongs to the Special Issue The dual role of ERK signaling in the apoptosis of neurons)
*Corresponding Author(s):  
Biao Cheng

Tendon injuries are very common in occupational and athletic settings, and the elderly population. Tendons repair and regenerate slowly and inefficiently in vivo after injury. The limited ability of tendons to self-repair and the general inefficiency of current treatment strategies have intensified the need for an effective therapeutic approach. Tendon-derived stem cells (TDSCs) have recently been identified within tendon tissues. TDSCs exhibit universal stem cell characteristics, such as clonogenicity, a high proliferative capacity, multi-differentiation potential, nonimmunogenicity, and immunosuppression. As a result, implanting TDSCs at damaged sites within tendons may be an effective way for tendon regeneration. This review summarizes the properties of TDSCs and discusses the advantages of its use in tendon tissue engineering.

Key words

Tendon, Tendon-Derived, Stem Cells, TDSCS, Regeneration, Tissue Engineering, Review

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Qiang Zhang, Biao Cheng. Tendon-derived stem cells as a new cell source for tendon tissue engineering. Frontiers in Bioscience-Landmark. 2013. 18(2); 756-764.