Open Access
Review

MicroRNAs in androgen-dependent PCa

Kai-Chang Zhu1,2,Jia-ju Lu1,Xiao-Lin Xu2,Jian-mei Sun3,*
1
Department of Urology, Provincial Hospital Affiliated to Shandong University,Jinan 250021, China
2
Department of Urology, Fengxian Branch of Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai, China
3
Department of Neonatology, Fengxian Branch of Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai, China
DOI: 10.2741/4137 Volume 18 Issue 2, pp.748-755
Published: 01 January 2013
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
*Corresponding Author(s):  
Jian-mei Sun
E-mail:  
zhukc210@yeah.net
Abstract

Prostate cancer (PCa) is the most commonly diagnosed cancer among men in Western countries and is one of the leading causes of cancer deaths. The growth and progression of PCa is related to androgen levels. In cancer, nicroRNAs (miRs) function as either oncogenes or tumor suppressor genes. In androgen-dependent PCa, miRs play a role in the growth, development, progression, and metastasis of the disease, and are also involved in the response to therapy and therefore affect the prognosis. In this review, we focus on the role played by miRs concerning the mechanisms of androgen-dependent PCa.

Key words

Prostate cancer, MicroRNAs, Single Nucleotide Polymorphisms, Review

Share and Cite
Kai-Chang Zhu, Jia-ju Lu, Xiao-Lin Xu, Jian-mei Sun. MicroRNAs in androgen-dependent PCa. Frontiers in Bioscience-Landmark. 2013. 18(2); 748-755.