Open Access

MicroRNA role in thyroid cancer pathogenesis

Xiaoping Zhang1,Haian Mao1,Zhongwei Lv1,*
Department of Nuclear Medicine, Shanghai 10th People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China
DOI: 10.2741/4135 Volume 18 Issue 2, pp.734-739
Published: 01 January 2013
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
*Corresponding Author(s):  
Zhongwei Lv

MicroRNAs (miRNAs) are a class of endogenous, non-coding RNAs approximately 22 nucleotides in length that negatively regulate translation of the protein-coding genes. As such, miRNAs are fundamental mediators of cellular differentiation, proliferation, and survival. Each miRNA may functionally interact with a multitude of target genes to exert various effects on normal physiology to support human health or pathological processes leading to disease conditions, such as cancer. Genome-wide analyses have generated specific miRNA profiles of thyroid cancers (TCs) and identified the up- and down-regulated miRNAs related to various carcinogenesis stages and prognoses. Here, we summarize the recent knowledge on aberrant miRNA expression in the various TCs, including papillary, follicular, and other rare types. In addition, we discuss the significance of miRNA profiles and individual miRNAs in the diagnosis, treatment, and prognosis of these tumors.

Key words

MicroRNA, Embryonic Stem Cells, Follicular Thyroid Cancer, Papillary Thyroid Cancer, Partially Differentiated Thyroid Cancer, Anaplastic Thyroid Cancer, Review

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Xiaoping Zhang, Haian Mao, Zhongwei Lv. MicroRNA role in thyroid cancer pathogenesis. Frontiers in Bioscience-Landmark. 2013. 18(2); 734-739.