Open Access

Confronting JC virus and Homo sapiens biological signatures

Guglielmo Lucchese1,2,*
Department of Biochemistry and Molecular Biology, University of Bari, Italy
Department of Neurological and Psychiatric Sciences, University of Bari, Italy
DOI: 10.2741/4133 Volume 18 Issue 2, pp.716-724
Published: 01 January 2013
(This article belongs to the Special Issue Peptides: from basic research to clinical applications)
*Corresponding Author(s):  
Guglielmo Lucchese

The present report describes the peptide commonality between JC virus (JCV) and the human proteome at the heptamer level. In total, 53 viral heptapeptides occur in functionally important human proteins with potential consequences for host functions and JCV pathogenesis. A paradigmatic example of a crucial peptide match is the SGKTTLA sequence, shared by JCV LT antigen and human nicotinamide/nicotinic acid riboside kinase, an enzyme involved in myelination processes. In general, the JCV- versus-host heptapeptide overlap may result in a competition between viral sequences and identical motifs in host enzymic active sites, adhesive domains, regulatory signaling motifs, etc., thus interfering with essential reactions and posing disadvantages to the cell. Overall, this study provides a starting point for investigating the role of peptide commonality in host- pathogen interactions.

Key words

JCV, JCV-vrs-human heptapeptide commonality, JCV-associated pathogenesis, NRK1

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Guglielmo Lucchese. Confronting JC virus and Homo sapiens biological signatures. Frontiers in Bioscience-Landmark. 2013. 18(2); 716-724.