Open Access

Matrix proteins as centralized organizers of negative-sense RNA virions

Lassi Liljeroos1,2,*,Sarah J. Butcher1
Institute of Biotechnology (Structural Biology and Biophysics), University of Helsinki, Helsinki, Finland
Department of Biosciences, P.O. Box 65,(Viikinkaari 1), FI-00014 University of Helsinki, Helsinki, Finland
DOI: 10.2741/4132 Volume 18 Issue 2, pp.696-715
Published: 01 January 2013
*Corresponding Author(s):  
Lassi Liljeroos

Matrix proteins are essential components of most negative-sense RNA, enveloped viruses. They serve a wide range of duties ranging from self-driven membrane budding and coordination of other viral components to modulation of viral transcription. The functional similarity between these proteins is striking, despite major differences in their structures. Whereas biochemical and structural studies have partly been hindered by the inherent aggregation properties of these proteins, their cellular functions are beginning to be understood. In this review we summarize the current knowledge on negative-sense RNA virus matrix proteins and their interactions with other viral and cellular proteins. We also discuss the similarities and differences in matrix protein functions between the different families within the negative-sense RNA viruses.

Key words

Matrix, Budding, Negative-strand, Paramyxovirus, Respiratory syncytial virus, Influenza, Rhabdovirus, VSV, Rabies, BDV, Arenavirus, LASV, L- domain, Review

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Lassi Liljeroos, Sarah J. Butcher. Matrix proteins as centralized organizers of negative-sense RNA virions. Frontiers in Bioscience-Landmark. 2013. 18(2); 696-715.