Open Access
Review

Serine protease and ovarian paracrine factors in regulation of ovulation

Yi-Xun Liu1,*,Xi-Ming Liu2,Liang-Fang Nin2,Lei Shi2,Su-Ren Chen1
1
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
2
Changsha Reproductive Medicine Hospital, Hunan, Changsha 410205, China
DOI: 10.2741/4128 Volume 18 Issue 2, pp.650-664
Published: 01 January 2013
(This article belongs to the Special Issue Gene regulation and signal transduction in gonads)
*Corresponding Author(s):  
Yi-Xun Liu
E-mail:  
liuyx@ioz.ac.cn
Abstract

The controlled target extracellular matrix (ECM) degradation generated by serine protease and regulated by serine protease inhibitor and ovarian paracrine/autocrine factors is an event that affects a wide variety of physiological and pathological processes in the ovary. Evidence cumulated in the past decade clearly showed that the hormone-induced coordinated expression of the tissuetype PA (tPA) produced mainly by granulosa cells and oocyte, and its inhibitor PAI-1 secreted by theca cells in the preovulatory follicles may be responsible for a controlled and directed proteolysis leading to the rupture of selected follicles in the rat, monkey and other mammals. In recent years increasing evidence further demonstrated that oocyte maturation and ovulation may also be modulated by other serine protease and inhibitor, as well as endogenously- produced ovarian paracrine/autocrine factors. Thus, it is important to identify the interrelationship between the serine protease system and the multiple factors, and to know how they regulate the ovarian physiological and pathological processes during oocyte maturation and ovulation.

Key words

Plasminogen Activator, Plasminogen Activator Inhibitor, Matrix Metalloproteinase, Protease Nexin-1, Paracrine/Autocrine Factor, Oocyte Maturation, Follicle Rupture, Review

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Yi-Xun Liu, Xi-Ming Liu, Liang-Fang Nin, Lei Shi, Su-Ren Chen. Serine protease and ovarian paracrine factors in regulation of ovulation. Frontiers in Bioscience-Landmark. 2013. 18(2); 650-664.