Open Access
Review

Inflammasomes: sensors of metabolic stresses for vascular inflammation

Ying Yin1,Jahaira Lopez Pastrana1,Xinyuan Li1,Xiao Huang1,Karthik Mallilankaraman3,Eric T. Choi2,Muniswamy Madesh3,Hong Wang1,Xiao-Feng Yang1,*
1
Department of Pharmacology, Cardiovascular Research Center, USA
2
Departments of Surgery, Temple University School of Medicine, Philadelphia, PA 19140, USA
3
Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
DOI: 10.2741/4127 Volume 18 Issue 2, pp.638-649
Published: 01 January 2013
(This article belongs to the Special Issue Amylin in vasodilation, energy expenditure and inflammation)
*Corresponding Author(s):  
Xiao-Feng Yang
E-mail:  
xfyang@temple.edu
Abstract

Metabolic syndrome is a major health issue in the western world. An elevated pro-inflammatory state is often found in patients with metabolic diseases such as type 2 diabetes and obesity. Atherosclerosis is one such clinical manifestation of pro-inflammatory state associated with the vasculature. The exact mechanism by which metabolic stress induces this pro-inflammatory status and promotes atherogenesis remained elusive until the discovery of the inflammasome protein complex. This complex is composed of pro-caspase-1 and pathogen sensors. Activation of inflammasome requires the transcriptional upregulation of inflammasome components and the post-translational assembly. Three models of inflammasome assembly have been proposed: 1) the ion channel model; 2) the reactive oxygen species (ROS) model; and 3) the lysosome model. In either case, inflammasome activation triggers the auto- activation of pro-caspase-1 into its mature form. Caspase-1, which was first discovered as the IL-1β converting enzyme, is known to be a major player in inflammatory and cell death pathways. Many endogenous metabolic ligands have been experimentally shown to activate inflammasome, and thus initiate the subsequent inflammation process. Further understanding of the distinct molecular mechanism by which metabolic ligands activates inflammasome could lead to developing novel therapeutic interventions for atherosclerosis and other clinical problems related to metabolic diseases.

Key words

Inflammasomes, Caspase-1, ROS, Vascular Inflammation, Interleukin-1 beta, Atherosclerosis, Review

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Ying Yin, Jahaira Lopez Pastrana, Xinyuan Li, Xiao Huang, Karthik Mallilankaraman, Eric T. Choi, Muniswamy Madesh, Hong Wang, Xiao-Feng Yang. Inflammasomes: sensors of metabolic stresses for vascular inflammation. Frontiers in Bioscience-Landmark. 2013. 18(2); 638-649.