Open Access
Article
Ovarian cancer as a genetic disease
Agnieszka Lech1,2,Teodora Daneva3,Shina Pashova3,Hristo Gagov4,Robert Crayton5,6,Wojciech Kukwa7,Anna M. Czarnecka1,*,Cezary Szczylik1
1
Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland
2
College of Inter-Faculty Individual Studies in Mathematics and Natural Sciences, University of Warsaw, Zwirki i Wigury 93, 02-089 Warsaw, Poland
3
Department of Imunobiology of Reproduction, Institute of Biology and Immunology of Reproduction, Sofia, Bulgaria
4
Department of Human and Animal Physiology, Faculty of Biology, St. Kliment Ohridski, University of Sofia, 1164 Sofia, Bulgaria
5
Department of Clinical and Experimental Physiology, Medical University of Warsaw, Warsaw, Poland
6
Department and Clinic of Urology, Faculty of Medical Sciences, Medical University of Warsaw, Warsaw, Poland
7
Department of Otolaryngology, Medical University of Warsaw, Stepinska 19/25, 00-739 Warsaw, Poland
DOI: 10.2741/4119 Volume 18 Issue 2, pp.543-563
Published: 01 January 2013
(This article belongs to the Special Issue Frontiers in molecular medicine)
*Corresponding Author(s):  
Anna M. Czarnecka
E-mail:  
aczarnecka@wim.mil.pl
Abstract

Ovarian cancer is characterized by the highest mortality rate among gynecologic malignancies. Therefore, there is a growing need for innovative therapies and techniques for monitoring and prevention of this disease. The exact cause of most ovarian tumors usually remains unknown. Ovarian cancer is believed to be caused by a range of different variables. This review is an attempt to summarize some genetic factors involved in the disruption of certain signaling pathways responsible for ovarian tumor transformation and development. Those factors considerably contribute to accurate diagnostics, treatment and prognosis in ovarian cancer.

Key words

Ovarian cancer, Cancerogenesis, Signaling pathway, BRCA1, BRCA2, TP53, PIK3CA, Review

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Agnieszka Lech, Teodora Daneva, Shina Pashova, Hristo Gagov, Robert Crayton, Wojciech Kukwa, Anna M. Czarnecka, Cezary Szczylik. Ovarian cancer as a genetic disease. Frontiers in Bioscience-Landmark. 2013. 18(2); 543-563.