Open Access
MicroRNA in the molecular mechanism of the circadian clock in mammals
Cheng Chu1,2,Zhongxin Zhao1,*
Department of Neurology, Institute of Neuroscience and MOE Key Laboratory of Molecular Neurobiology, Neuroscience Research Center of Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China
Department of Neurology, The First People’s Hospital of Yangzhou, 45 Taizhou Road, Yangzhou 225001, Jiangsu Province, China
DOI: 10.2741/4112 Volume 18 Issue 2, pp.441-446
Published: 01 January 2013
(This article belongs to the Special Issue The dual role of ERK signaling in the apoptosis of neurons)
*Corresponding Author(s):  
Zhongxin Zhao

The biochemical activity of mammals is controlled by an internal timekeeping mechanism driving a clock to run in approximate 24-hour (circadian) cycles. In mammals, this circadian clock is located both in the suprachiasmatic nuclei (SCN) and peripheral oscillators. Recently, microRNAs have emerged as significant players in circadian clock timing. The biological implications of miRNAs are extended further by recent studies that microRNAs are expressed in the SCN and peripheral circadian oscillators. In this study, we review recent work revealing the role of microRNAs in the molecular mechanism of circadian clock in mammals.

Key words

MicroRNA, Circadian Clock, Mammals, Review

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Cheng Chu, Zhongxin Zhao. MicroRNA in the molecular mechanism of the circadian clock in mammals. Frontiers in Bioscience-Landmark. 2013. 18(2); 441-446.