MicroRNA in the molecular mechanism of the circadian clock in mammals
Department of Neurology, Institute of Neuroscience and MOE Key Laboratory of Molecular Neurobiology, Neuroscience Research Center of Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China
Department of Neurology, The First People’s Hospital of Yangzhou, 45 Taizhou Road, Yangzhou 225001, Jiangsu Province, China
01 January 2013
The biochemical activity of mammals is
controlled by an internal timekeeping mechanism driving a
clock to run in approximate 24-hour (circadian) cycles. In
mammals, this circadian clock is located both in the
suprachiasmatic nuclei (SCN) and peripheral oscillators.
Recently, microRNAs have emerged as significant players
in circadian clock timing. The biological implications of
miRNAs are extended further by recent studies that
microRNAs are expressed in the SCN and peripheral
circadian oscillators. In this study, we review recent work
revealing the role of microRNAs in the molecular
mechanism of circadian clock in mammals.
MicroRNA, Circadian Clock, Mammals,
Share and Cite
Cheng Chu, Zhongxin Zhao. MicroRNA in the molecular mechanism of the circadian clock in mammals. Frontiers in Bioscience-Landmark. 2013. 18(2); 441-446.