Open Access
Review
Mechanisms of cardioprotection by isoflurane against I/R injury
Xiao-E Lang1,*,Xiong Wang1,Jian-Hua Jin2
1
Department of Cardiology, First Hospital, Shanxi Medical University, Taiyuan Shanxi, P. R. China
2
Department of Psychiatry, First Hospital, Shanxi Medical University, Taiyuan Shanxi, P. R. China
DOI: 10.2741/4109 Volume 18 Issue 1, pp.387-393
Published: 01 January 2013
*Corresponding Author(s):  
Xiao-E Lang
E-mail:  
xiaoelang@yeah.net
Abstract

Myocardial infarction is responsible for most cardiovascular mortality as well as the pathogenesis of myocardial damage during and after infarction. Efforts are underway to modulate the development of ischemia– reperfusion (I–R) injury. Recently, the protective effect of isoflurane against myocardial I–R injury emerged as a possibility. Nitric oxide, nitric oxide synthases, factors related to energy metabolism, adenosine triphosphate- sensitive potassium channels, phosphatidylinositol-3-kinase and hypoxia-inducible factor1-alpha have been shown to participate in the mechanisms of cardioprotection elicited by isoflurane against I–R injury. In this review, we focus on the mechanisms of cardioprotection offered by isoflurane against I–R injury.

Key words

Ischemia and reperfusion; HIF 1-alpha; inducible NOS, Review

Share and Cite
Xiao-E Lang, Xiong Wang, Jian-Hua Jin. Mechanisms of cardioprotection by isoflurane against I/R injury. Frontiers in Bioscience-Landmark. 2013. 18(1); 387-393.