Open Access
Prevalence and risk factor for MDR-GNB infection in liver transplantation
Lin Zhong1,*,Tong-Yi Men2,Hao Li3,Yan Gu1,Xin Ding1,Tong-Hai Xing1,Jun-Wei Fan1,Zhi-Hai Peng1
Department of General Surgery, Shanghai First People Hospital, Medical School of Shanghai Jiaotong University,85 Wu Jing Road,200080,Shanghai, People’s Republic of China
Department of Urology, Shandong Province Qianfoshan Hospital, Shandong University, Jinan 250014, People’s Republic of China
Shandong Academy of Medical Science, Jinan 250062, People’s Republic of China
DOI: 10.2741/4107 Volume 18 Issue 1, pp.366-370
Published: 01 January 2013
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
*Corresponding Author(s):  
Lin Zhong

Liver transplantation (LT) has emerged as a viable therapy for various end-stage liver diseases. Multi- drug resistant Gram-negative bacilli (MDR-GNB) have emerged as predominant pathogens. The prevalence of MDR-GNB infection has been increasing in LT recipients, especially in early post-LT stages. MDR-GNB infection has become a main cause of death following LT. Since key elements of MDR-GNB infection after LT mainly include the pre-LT severity of underlying disease, technical problems, acute rejection, and so on, appropriate measures, such as improvement of LT technology and management, restriction of antibiotic use and immunosuppressive therapy advancement, should be commenced to prevent and control the occurrence of MDR-GNB infection. A better understanding of the prevalence of and risk factors for MDR-GNB infection complications is needed to improve quality of life and survival rate after LT.

Key words

Liver transplantation, Multi-Drug Resistant Gram-Negative Bacilli, Orthotopic Liver Transplantation, Review

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Lin Zhong, Tong-Yi Men, Hao Li, Yan Gu, Xin Ding, Tong-Hai Xing, Jun-Wei Fan, Zhi-Hai Peng. Prevalence and risk factor for MDR-GNB infection in liver transplantation. Frontiers in Bioscience-Landmark. 2013. 18(1); 366-370.