Open Access
Roles of heat-shock protein 70 in protecting against intestinal mucosal damage
Xin Wu1,2,Yuzhe Zhang1,Yulong Yin1,2,*,Zheng Ruan2,Huimin Yu3,Zhenlong Wu4,Guoyao Wu4,5
Hunan Engineering and Research Center of Animal and Poultry Science, Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan, 410125, China
State Key Laboratory of Food Science and Technology and College of Life Science and Food Engineering, Nanchang University, Nanchang 330031, China
Feed Research Institute Chinese Academy of Agricultural Science, Beijing, China
State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, 100193, China
Department of Animal Science, Texas A&M University, College Station, TX, 77843, USA
DOI: 10.2741/4106 Volume 18 Issue 1, pp.356-365
Published: 01 January 2013
(This article belongs to the Special Issue Amino acids in nutrition, health, and disease)
*Corresponding Author(s):  
Yulong Yin

Heat shock proteins (HSPs) are remarkably conserved in all living organisms. The upregulation of expression of HSPs is triggered by a variety of physiological and environmental insults. HSPs play an important role in protecting against protein denaturation and subsequent celluar stress, which damages the intestinal mucosa and reduces the protective function of the mucosal barrier, resulting in the formation of stress ulcers. Heat shock protein 70 (HSP70) is the most widely studied of all HSPs and has numerous important chaperoning functions. Stress accelerates the synthesis of HSP70, which in turn inhibits the apoptosis of intestinal mucosal cells. In this article, we review the main classification of HSPs, the expression and regulation of HSPs and their roles in stress ulcers. We also discuss the role of functional amino acids in regulating the expression of HSPs (particularly HSP70) and protecting the intestinal mucosa and other tissues.

Key words

Heat shock proteins; HSP70; Functional amino acids; Glutamine; Arginine, Review

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Xin Wu, Yuzhe Zhang, Yulong Yin, Zheng Ruan, Huimin Yu, Zhenlong Wu, Guoyao Wu. Roles of heat-shock protein 70 in protecting against intestinal mucosal damage. Frontiers in Bioscience-Landmark. 2013. 18(1); 356-365.