Open Access
Article
BlyS: a potential hallmark of multiple myeloma
Ping Wang1,Liu Qian2,Xiangliang Yuan1,Chaoying Hu2,Liansheng Wang1,Qiuyu Huang2,Ping Miao2,Qiwen Yu2,Yanhui Ma1, Jiying Zhang2,Xuehua Chen3,Bingya Liu3,Lisong Shen1,Dongqing Zhang2,*
1
Shanghai JiaoTong University School of Medicine, Xinhua Hospital, 1665 Kongjiang Road, Shanghai 200092, China
2
Shanghai JiaoTong University School of Medicine, Shanghai Institute of Immunology, 227 South Chongqing Road, Shanghai 200025, China
3
Shanghai JiaoTong University School of Medicine, Ruijin Hospital, 197 Ruijin Er road, Shanghai 200025, China
DOI: 10.2741/4103 Volume 18 Issue 1, pp.324-331
Published: 01 January 2013
(This article belongs to the Special Issue Immune pathology)
*Corresponding Author(s):  
Dongqing Zhang
E-mail:  
dqzhang1333@yahoo.com.cn
Abstract

Multiple myeloma (MM) is a plasma cell dyscrasia characterized by bone lesions and production of a paraprotein. B-lymphocyte stimulator (BLyS) and its receptor (BAFFR) were highly expressed on peripheral blood and bone marrow B cells in MM patients as compared to those with monoclonal gammopathy of unknown significance (MGUS) and healthy donors. Serum BLyS levels in MM patients were significantly higher than those in MGUS patients and healthy controls. BLyS expression was increased in bone marrow specimens from MM patients as ascertained by immunofluorescence. Furthermore, BLyS, together with IL-2 and IL-6, significantly promoted MM cell proliferation and BLyS receptor expression compared with that in the control group. Treatment with bortezomib, a therapeutic proteasome inhibitor induced apoptosis and repressed the proliferation of RPMI8226 and U266 cells through inhibition of NF-κB p65 and IκBα. These findings suggest that BLyS is involved in the immunopathogenesis of MM and may prove to be a hallmark of MM.

Key words

Multiple myeloma, B-lymphocyte stimulator, NFkappaB

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Ping Wang, Liu Qian, Xiangliang Yuan, Chaoying Hu, Liansheng Wang, Qiuyu Huang, Ping Miao, Qiwen Yu, Yanhui Ma, Jiying Zhang, Xuehua Chen, Bingya Liu, Lisong Shen, Dongqing Zhang. BlyS: a potential hallmark of multiple myeloma. Frontiers in Bioscience-Landmark. 2013. 18(1); 324-331.