Open Access

Non-syndromic thoracic aortic aneurysms and dissections-a genetic review

Pengyu Zhang1,Eryong Zhang1,*,Jingxiu Fan1,Jun Gu1
Cardiovascular and Thoracic Surgery Department, West China Hospital of Sichuan University, Chengdu, China
DOI: 10.2741/4101 Volume 18 Issue 1, pp.305-311
Published: 01 January 2013
*Corresponding Author(s):  
Eryong Zhang

Thoracic aortic aneurysm and dissections (TAADs) are associated with both high mortality and medical expense. Poor outcomes are preventable by surgical repair; however, identifying individuals at-risk is difficult. Researchers are scanning the human genome to characterize the genetic determinants of TAADs by identifying chromosomal regions, gene mutations, single nucleotide polymorphism (SNP), genomic copy number variants and micro-RNA variants, with the purpose of analyzing the risk of TAADs associated with these predisposing genes. The goal of this review is to develop screening tests to identify individuals at risk for non- syndromic TAADs. This genetic survey has significant clinical implications because high-risk individuals can be closely monitored and can benefit from preventative surgical repair.

Key words

Thoracic Aortic Aneurysms; Genetic Analysis; Single Nucleotide Polymorphism, Review

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Pengyu Zhang, Eryong Zhang, Jingxiu Fan, Jun Gu. Non-syndromic thoracic aortic aneurysms and dissections-a genetic review. Frontiers in Bioscience-Landmark. 2013. 18(1); 305-311.