Open Access
Review
Role of TSG101 in cancer
Yun Jiang1,Yu Ou1,Xiaodong Cheng2,*
1
School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China
2
Department of Pharmacology and Toxicology, The University of Texas Medical Brach, Galveston, Texas 77555-0615, USA
DOI: 10.2741/4099 Volume 18 Issue 1, pp.279-288
Published: 01 January 2013
(This article belongs to the Special Issue Frontiers in molecular medicine)
*Corresponding Author(s):  
Xiaodong Cheng
E-mail:  
xcheng@utmb.edu
Abstract

The tumor susceptibility gene 101 (TSG101) encodes a multidomain protein that contains a UEV (ubiquitin e2 variant) domain at is N-terminus and a putative DNA-binding motif at its C-terminus. In addition to being a bona fide component of the ESCRT (endosomal sorting complexes required for transport) complex 1 and playing a critical role in endosomal sorting and trafficking, TSG101 has also been implicated in an array of cellular functions including, cytokinesis, protein ubiquitination, transcriptional regulation, cell cycle and proliferation, as well as viral budding. The major focus of this article is on the role of TSG101 in tumorigenesis.

Key words

TSG101, Cancer, Tumorigenesis, Endosomal Sorting, Ubiquitination, Cytokinesis, Cell Proliferation, Review

Share and Cite
Yun Jiang, Yu Ou, Xiaodong Cheng. Role of TSG101 in cancer. Frontiers in Bioscience-Landmark. 2013. 18(1); 279-288.