Open Access
Review
The power of yeast to model diseases of the powerhouse of the cell
Matthew G. Baile1,Steven M. Claypool1,*
1
Department of Physiology, Johns Hopkins School of Medicine, Baltimore, MD 21205-2185, USA
DOI: 10.2741/4098 Volume 18 Issue 1, pp.241-278
Published: 01 January 2013
(This article belongs to the Special Issue The yeast model: its contribution to understanding human disease)
*Corresponding Author(s):  
Steven M. Claypool
E-mail:  
sclaypo1@jhmi.edu
Abstract

Mitochondria participate in a variety of cellular functions. As such, mitochondrial diseases exhibit numerous clinical phenotypes. Because mitochondrial functions are highly conserved between humans and Saccharomyces cerevisiae, yeast are an excellent model to study mitochondrial disease, providing insight into both physiological and pathophysiological processes.

Key words

Mitochondria, Oxidative Phosphorylation, Mitochondrial Disease, Saccharomyces cerevisiae, Review

Share and Cite
Matthew G. Baile, Steven M. Claypool. The power of yeast to model diseases of the powerhouse of the cell. Frontiers in Bioscience-Landmark. 2013. 18(1); 241-278.