Open Access
Article
Strong correlation between diet and development of colorectal cancer
Alessandro Cappellani1,Antonio Zanghì1,Maria Di Vita1,*,Andrea Cavallaro1,Gaetano Piccolo1,Pierfrancesco Veroux2,Emanuele Lo Menzo3,Vincenzo Cavallaro4,Paolo de Paoli5,Massimiliano Veroux2,Massimiliano Berretta6
1
Department of Surgery, General Surgery and Breast Unit, University of Catania, Azienda Ospedaliero-Universitaria, Policlinico Vittorio Emanuele, via S. Sofia, 78, 95123 Catania, Italy
2
Department of Surgery, Transplantation and Advanced Technologies, University of Catania, Italy
3
Division of Laparoscopic and Bariatric Surgery, University of Maryland, Baltimore, MD, USA
4
Department of Surgery, Digestive Surgery Unit, University of Catania, Azienda Ospedaliero-Universitaria Policlinico, Vittorio Emanuele, via S. Sofia, 78, 95123 Catania, Italy
5
Scientific Direction, National Cancer Institute, I.R.C.C.S., via Franco Gallini 2, 33081 Aviano (PN), Italy
6
Department of Medical Oncology, National Cancer Institute, I.R.C.C.S., via Franco Gallini 2, 33081 Aviano (PN), Italy
DOI: 10.2741/4095 Volume 18 Issue 1, pp.190-198
Published: 01 January 2013
(This article belongs to the Special Issue Dietary approaches to prevent chronic-degenerative diseases)
*Corresponding Author(s):  
Maria Di Vita
E-mail:  
maria.divita@tiscali.it
Abstract

Multiple factors have been described among the causes of non-hereditary colorectal cancer. In Western countries, the most common risk factors include upper- middle socioeconomic status and dietary regimens rich in proteins and animal fats. High consumption of red meats, smoked foods, cold cuts, or canned foods is believed to contribute to carcinogenesis as they directly affect epithlial turnover and cause metabolism of biliary acids. Dietary fibers have protective effects in that they capture the fats and biliary acids, thereby inhibiting their activity. Tobacco smoking acts both locally and systemically on the colorectal mucosa through the production of carcinogenic agents. Finally, the action of alcohol, in association with nicotine addiction, also increases the risk of developing colorectal tumors. Knowledge of dietary and environmental factors is of paramount importance in implementing preventive strategies for colorectal cancer.

Key words

Colorectal cancer, Dietary habits, Fibers Intake, Folate, Meat Intake, Methylation, Obesity, Review

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Alessandro Cappellani, Antonio Zanghì, Maria Di Vita, Andrea Cavallaro, Gaetano Piccolo, Pierfrancesco Veroux, Emanuele Lo Menzo, Vincenzo Cavallaro, Paolo de Paoli, Massimiliano Veroux, Massimiliano Berretta. Strong correlation between diet and development of colorectal cancer. Frontiers in Bioscience-Landmark. 2013. 18(1); 190-198.