Open Access
Platelet-derived growth factor signaling in mesenchymal cells
Johanna Donovan1,*,David Abraham1,Jill Norman2
Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Campus, London, UK
Centre for Nephrology, Division of Medicine, UCL Medical School, Royal Free Campus, London, UK
DOI: 10.2741/4090 Volume 18 Issue 1, pp.106-119
Published: 01 January 2013
(This article belongs to the Special Issue Signaling in tissue repair and fibrosis)
*Corresponding Author(s):  
Johanna Donovan

Platelet-derived growth factors (PDGFs) and their receptors are major mitogens for many cell types of mensenchymal origin, including fibroblasts and vascular smooth muscle cells (VSMCs). Their role in enhancing migratory and proliferative responses and extracellular matrix synthesis in these cells, make them key regulators of critical biological functions and in tissue diseases including tissue remodeling, scarring and fibrosis. The activities of the PDGFs have been extensively characterized at the molecular and cellular level and in in vivo model systems. This, in turn, has lead to an increasing number of PDGF-based therapies designed to accelerate or combat defects in tissue repair. This review aims to summarize recent developments in the role of PDGF in key mesenchymal cell functions. Many of the current developments in this field have primarily focused on advancements in understanding cell differentiation, migration, proliferation and the development of emerging PDGF-based therapies and hence will be primary focus of this review.

Key words

PDGF, PDGFR, Fibroblast, Vascular smooth muscle cell, Chondrocyte, Osteoblast, Osteoclast, Review

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Johanna Donovan, David Abraham, Jill Norman. Platelet-derived growth factor signaling in mesenchymal cells. Frontiers in Bioscience-Landmark. 2013. 18(1); 106-119.