Open Access

Epigenetic regulation of transcription in Drosophila

Aishwarya Swaminathan1,2,Ambikai Gajan1,Lori A Pile1,*
Department of Biological Sciences, Wayne State University, Detroit, Michigan, 48202, USA
Current address: Department of Microbiology, University of Massachusetts, Amherst, Massachusetts, 01003, USA
DOI: 10.2741/3964 Volume 17 Issue 3, pp.909-937
Published: 01 January 2012
(This article belongs to the Special Issue Epigenetic effects during development and disease launch)
*Corresponding Author(s):  
Lori A Pile

Post-translational modification of histones is a major mechanism of epigenetic regulation of eukaryotic transcription. Drosophila has proven to be an important model system for the study of histone modifying enzymes and the cross talk that occurs between the various modifications. Polytene chromosome analysis and genome-wide chromatin immunoprecipitation (ChIP) studies have provided much insight into the location of marks and many of the enzymes that perform the catalytic reactions. Gene specific effects have been determined through study of flies carrying mutations in histone modifying enzymes. This review will highlight classic studies and present recent progress on both the localization data and mutant analyses. This information has been used to assign function to the marks and to the enzymes that place or remove them, critical for the process of transcriptional regulation.

Key words

Chromatin, Drosophila, Epigenetics, Histone modification, Transcription, Review

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Aishwarya Swaminathan, Ambikai Gajan, Lori A Pile. Epigenetic regulation of transcription in Drosophila. Frontiers in Bioscience-Landmark. 2012. 17(3); 909-937.