Open Access
Cooperative Hedgehog-EGFR signaling
Doris Mangelberger1,Daniela Kern1,Andrea Loipetzberger1,Markus Eberl1,Fritz Aberger1,*
Division of Molecular Tumor Biology, Department of Molecular Biology, University of Salzburg, Salzburg, Austria
DOI: 10.2741/3917 Volume 17 Issue 1, pp.90-99
Published: 01 January 2012
*Corresponding Author(s):  
Fritz Aberger

It has been known for many years that cooperative interactions between oncogenes (e.g. RAS, MYC, BCL2) can fuel cancer growth (1-5), but the restricted druggability of many of those interacting cancer genes has hampered translation of combined targeting to medical cancer therapy. The identification and characterization of cooperative cancer signaling pathways amenable to medical therapy is therefore a crucial step towards the establishment of efficient targeted combination treatments urgently needed to improve cancer therapy. Here we review recent findings of our group and colleagues on the molecular mechanisms of cooperative Hedgehog/GLI and Epidermal Growth Factor Receptor (EGFR) signaling, two clinically relevant oncogenic pathways involved in the development of many human malignancies. We also discuss the possible implications of these findings for the design of a therapeutic regimen relying on combined targeting of key effectors of both pathways.

Key words

Hedgehog signaling, Epidermal growth factor receptor, GLI transcription factors, JUN/AP-1 transcription factors, MEK/ERK Signaling, Oncogenic Transformation, Cancer, Combination Therapy, Review

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Doris Mangelberger, Daniela Kern, Andrea Loipetzberger, Markus Eberl, Fritz Aberger. Cooperative Hedgehog-EGFR signaling. Frontiers in Bioscience-Landmark. 2012. 17(1); 90-99.