Open Access
Structure and regulation of the c-Fes protein-tyrosine kinase
Sabine Hellwig1,Thomas E Smithgall1
Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA
DOI: 10.2741/3902 Volume 16 Issue 8, pp.3146-3155
Published: 01 June 2011

The c-Fes protein-tyrosine kinase is the normal cellular ortholog of several avian and feline retroviral oncoproteins. Unlike its transforming viral counterparts, c-Fes tyrosine kinase activity is tightly regulated in vivo through a mechanism involving coiled-coil oligomerization domains and other unique structural features found in its long N-terminal region. This review is focused on the regulatory features and structural biology of c-Fes, which has been implicated in normal cellular growth regulation, the innate immune response, and tumorigenesis.

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Sabine Hellwig, Thomas E Smithgall. Structure and regulation of the c-Fes protein-tyrosine kinase. Frontiers in Bioscience-Landmark. 2011. 16(8); 3146-3155.