Open Access
Crosstalk between viruses and PML nuclear bodies: a network-based approach
Ellen Van Damme1,Xaveer Van Ostade1
Laboratory of Protein Science, Proteomics and Epigenetic Signal Transduction, Department of Biomedical Sciences, University of Antwerp (Campus Drie Eiken), Universiteitsplein 1, Building T, 2610 Wilrijk, Belgium
DOI: 10.2741/3889 Volume 16 Issue 8, pp.2910-2920
Published: 01 June 2011

Due to the recent advances in instrumental and scientific methods, cell biology data are generated with increasing speed and quantity. One of these fast developing fields is the crosstalk between promyelocytic leukemia protein nuclear bodies (PML-NBs) and viruses. PML-NBs are dynamic nuclear protein aggregates which are targeted by entire viral particles, viral proteins or viral nucleic acids. Their possible anti-viral properties motivated researchers to investigate the interaction between PML-NBs and viruses in depth. Based on extensive literature data mining, we created a comprehensive PML-NB/virus crosstalk Cytoscape network, which groups not only the most common relations but also less well described findings. The network is easy to navigate and provides a biologically relevant overview which can help finding interesting case studies.

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Ellen Van Damme, Xaveer Van Ostade. Crosstalk between viruses and PML nuclear bodies: a network-based approach. Frontiers in Bioscience-Landmark. 2011. 16(8); 2910-2920.