Open Access
Article
Molecular regulation of the intestinal epithelial barrier: implication in human diseases
Zhihua Liu1,Chenzhang Shi1,Jianjun Yang1,Peng Zhang1,Yanlei Ma1,Feng Wang1,Huanlong Qin1
1
Department of Surgery, Shanghai JiaoTong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China
DOI: 10.2741/3888 Volume 16 Issue 8, pp.2903-2909
Published: 01 June 2011
(This article belongs to the Special Issue Immunoregulation and inflammatory disease)
Abstract

Intestinal barrier dysfunction is implicated in the development of various clinical diseases. While the study of intestinal barrier function has traditionally emphasized the impact of intestinal microflora and bacteria, the rapid development of molecular and cellular techniques has helped the recent transition of the field to the molecular regulation of the intestinal epithelial barrier. In this review, we summarized several aspects of recent progress on the molecular regulation of the intestinal epithelial barrier, ranging from the extrinsic factors such as probiotics, intrinsic protein effectors including the tight junction proteins, intestinal alkaline phosphatase and protein phosphatase 2A, to intestinal cell subsets such as intestinal intraepithelial lymphocytes and intestinal stem cells. Further investigations into the detailed mechanisms underlying the molecular regulation of the intestinal epithelial barrier will enable our manipulation of the factors and cell subsets involved to develop effective approaches to treat intestinal barrier dysfunction associated diseases.

Share and Cite
Zhihua Liu, Chenzhang Shi, Jianjun Yang, Peng Zhang, Yanlei Ma, Feng Wang, Huanlong Qin. Molecular regulation of the intestinal epithelial barrier: implication in human diseases. Frontiers in Bioscience-Landmark. 2011. 16(8); 2903-2909.