Open Access
JAK-STAT signaling in hepatic fibrosis
Markus Mair1,Leander Blaas1,Christoph H Österreicher1,Emilio Casanova1,Robert Eferl1
Ludwig Boltzmann Institute for Cancer Research, Waehringer Strasse 13a, A-1090 Vienna, Austria
DOI: 10.2741/3886 Volume 16 Issue 8, pp.2794-2811
Published: 01 June 2011
(This article belongs to the Special Issue Regulation of signalling in health and disease)

Chronic liver injury, liver fibrosis and formation of hepatocellular carcinoma are intimately linked and represent a major medical challenge since treatment options are limited. Therefore, it is important to identify cellular and molecular pathways that promote liver damage or provide hepatoprotection for development of therapeutic approaches. Recently, the transcription factors STAT3 and STAT5 have been implicated in liver fibrosis induced by cholestatic liver damage. In this review, we summarize our current knowledge about STAT proteins in liver fibrosis and focus on common activities that underlie the hepatoprotective mechanisms regulated by IL-6/gp130/STAT3 and GH/STAT5/IGF-1 signaling pathways.

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Markus Mair, Leander Blaas, Christoph H Österreicher, Emilio Casanova, Robert Eferl. JAK-STAT signaling in hepatic fibrosis. Frontiers in Bioscience-Landmark. 2011. 16(8); 2794-2811.