Open Access
Alternative splicing of RAGE: roles in biology and disease
Anastasia Z Kalea1,Ann Marie Schmidt1,Barry I Hudson1
Division of Nephrology/Hypertension, Feinberg School of Medicine, Northwestern University, IL, USA
DOI: 10.2741/3884 Volume 16 Issue 7, pp.2756-2770
Published: 01 June 2011
(This article belongs to the Special Issue RAGE signaling)

The Receptor for Advanced Glycation End-products (RAGE) is a complex, multi-ligand signaling system implicated in the pathogenesis of diabetes, cardiovascular disease and various cancers. RAGE undergoes extensive alternative splicing to produce a variety of transcripts with diverse functions, including soluble antagonists and variants with altered ligand binding domains. Studies focused on the major soluble variant (RAGEv1/esRAGE) have revealed this to function by binding RAGE-ligands and preventing activation of RAGE signaling in vascular and tumor cells. Furthermore, measurement of this variant in human serum has revealed that RAGEv1/esRAGE levels may represent a novel biomarker for RAGE-ligand related pathogenic states. Understanding the full plethora of RAGE alternative splicing and its regulation is central to elucidating the role of RAGE in biology and disease.

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Anastasia Z Kalea, Ann Marie Schmidt, Barry I Hudson. Alternative splicing of RAGE: roles in biology and disease. Frontiers in Bioscience-Landmark. 2011. 16(7); 2756-2770.