Open Access
RAS and Hedgehog--partners in crime
Matthias Lauth1
Institute of Molecular Biology and Tumor Research (IMT), Philipps University, 35037 Marburg, Germany.
DOI: 10.2741/3852 Volume 16 Issue 6, pp.2259-2270
Published: 01 June 2011
(This article belongs to the Special Issue Hedgehog signaling)

Both RAS and Hedgehog (HH) pathway activation can be found in approximately one third of all cancers. In many cases, this activation occurs in the same tumor types, suggesting a positive impact of a simultaneous activation of RAS and HH on tumor development. This review aims to summarize the current knowledge about the molecular and functional crosstalk of RAS and HH signaling in the development of hyperproliferative disease.

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Matthias Lauth. RAS and Hedgehog--partners in crime. Frontiers in Bioscience-Landmark. 2011. 16(6); 2259-2270.