Open Access
The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis
Laura Wagstaff1,Richard Kelwick1,Julie Decock1,Dylan R Edwards1
Wellcome Trust/Cancer Research UK Gurdon Institute, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
DOI: 10.2741/3827 Volume 16 Issue 5, pp.1861-1872
Published: 01 January 2011
(This article belongs to the Special Issue Bone metastasis, the molecular, cellular and clinical prospects)

The human ADAMTS (a disintegrin and metalloproteinase with thrombospondin-like motifs) family of 19 secreted, multidomain proteolytic enzymes is involved in a wide range of biological processes including ECM assembly and degradation, hemostasis, organogenesis and the regulation of angiogenesis. Defects in certain family members give rise to inherited human genetic diseases, while aberrant expression of other ADAMTSs has been linked to the pathogenesis of arthritis and cancer. Several ADAMTSs act as tumor or metastasis suppressors whose functions are lost either by mutation or epigenetic silencing during tumor progression. This review looks in depth at the involvement of ADAMTSs as positive and negative mediators in cancer growth and spread.

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Laura Wagstaff, Richard Kelwick, Julie Decock, Dylan R Edwards. The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis. Frontiers in Bioscience-Landmark. 2011. 16(5); 1861-1872.