Open Access
KSRP, many functions for a single protein
Paola Briata1,Ching-Yi Chen1,Matteo Giovarelli1,Michela Pasero1,Michele Trabucchi1,Andres Ramos1,Roberto Gherzi1
Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
DOI: 10.2741/3821 Volume 16 Issue 5, pp.1787-1796
Published: 01 January 2011
(This article belongs to the Special Issue RNA binding proteins in disease)

KSRP is a single-strand nucleic acids binding protein that affects RNA fate at multiple levels. KSRP modular structure and its complex pattern of post-translational modifications underpin the interaction with a wide spectrum of RNA target sequences, as well as with other RNA-binding proteins and molecular adaptors. These interactions are important to the regulation of different steps of mRNA metabolism and, in turn, modulate several aspects of cellular proliferation and differentiation. In this review we will discuss in detail KSRP ability to i) promote decay of labile mRNAs interacting with some components of the mRNA decay machinery and ii) favor the maturation of a select group of microRNA precursors.

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Paola Briata, Ching-Yi Chen, Matteo Giovarelli, Michela Pasero, Michele Trabucchi, Andres Ramos, Roberto Gherzi. KSRP, many functions for a single protein. Frontiers in Bioscience-Landmark. 2011. 16(5); 1787-1796.