Open Access
Article
Associations between adipokines and obesity-related cancer
Gilberto Paz-Filho1,Ee Lyn Lim1,Ma-Li Wong1,Julio Licinio1
1
Department of Translational Medicine, The John Curtin School of Medical Research, The Australian National University, Garran Rd, building 131, Canberra, Australia
DOI: 10.2741/3810 Volume 16 Issue 5, pp.1634-1650
Published: 01 January 2011
(This article belongs to the Special Issue Obesity and cancer)
Abstract

There is increasing evidence that obesity may have pathophysiological effects that extend beyond its well-known co-morbidities; in particular its role in cancer has received considerable epidemiological support. As adipose tissue becomes strongly established as an endocrine organ, two of its most abundant and most investigated adipokines, leptin and adiponectin, are also taken beyond their traditional roles in energy homeostasis, and are implicated as mediators of the effects of obesity on cancer development. This review examines these adipokines in relation to the prostate, breast, colorectal, thyroid, renal, pancreatic, endometrial and oesophageal cancers, and how they may orchestrate the influence of obesity on the development of these malignancies.

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Gilberto Paz-Filho, Ee Lyn Lim, Ma-Li Wong, Julio Licinio. Associations between adipokines and obesity-related cancer. Frontiers in Bioscience-Landmark. 2011. 16(5); 1634-1650.