Open Access
The FERM family proteins in cancer invasion and metastasis
Hefen Yu1,Yuxiang Zhang1,Lin Ye1,Wen G Jiang1
Department of Biochemistry and Molecular Biology, School of Basic Medicine, Capital Medical University, Beijing, PR China.
DOI: 10.2741/3803 Volume 16 Issue 4, pp.1536-1550
Published: 01 January 2011
(This article belongs to the Special Issue Bone metastasis, the molecular, cellular and clinical prospects)

Metastasis is the major cause of death in patients with cancer. Metastatic cancer cells undergo dramatic molecular and cellular changes by remodeling their cell-cell and cell-matrix adhesion and their actin cytoskeleton, molecular processes that involve the activity of various signaling networks. The FERM family proteins can link transmembrane proteins to the cytoskeleton or link kinase and/or phosphatase enzymatic activity to the plasma membrane. They thus are involved not only in cell-extracellular matrix interactions and cell-cell communication but also in apoptosis, carcinogenesis and metastasis. This review will summarize the role and mechanism of FERM proteins, with particular reference to the ERM and Ehm2 proteins in cancer metastasis.

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Hefen Yu, Yuxiang Zhang, Lin Ye, Wen G Jiang. The FERM family proteins in cancer invasion and metastasis. Frontiers in Bioscience-Landmark. 2011. 16(4); 1536-1550.