Open Access
Article
Regulation of MDM4
Michael P Markey1
1
Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA. michael.markey@wright.edu
DOI: 10.2741/3780 Volume 16 Issue 3, pp.1144-1156
Published: 01 January 2011
Abstract

Mouse double minute 4 (MDM4), also known as MDMX or HDMX (human MDMX), is a critical negative regulator of the tumor suppressor p53. Under normal growth conditions, MDM4 contributes to the repression of p53 activity. Upon DNA damage, it becomes important to down-regulate MDM4 to allow a full p53 response. Here, the mechanisms by which MDM4 activity is controlled are reviewed and discussed, starting with alterations in copy number, then control of transcription, mRNA stability, translation, and finally post-translational interactions, modifications, localization, and targeting by recently developed drugs.

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Michael P Markey. Regulation of MDM4. Frontiers in Bioscience-Landmark. 2011. 16(3); 1144-1156.