Open Access
Article
Myb proteins: angels and demons in normal and transformed cells
Ye Zhou1,Scott A Ness1
1
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131-0001, USA
DOI: 10.2741/3738 Volume 16 Issue 3, pp.1109-1131
Published: 01 January 2011
Abstract

A key regulator of proliferation, differentiation and cell fate, the c-Myb transcription factor regulates the expression of hundreds of genes and is in turn regulated by numerous pathways and protein interactions. However, the most unique feature of c-Myb is that it can be converted into an oncogenic transforming protein through a few mutations that completely change its activity and specificity. The c-Myb protein is a myriad of interactions and activities rolled up in a protein that controls proliferation and differentiation in many different cell types. Here we discuss the background and recent progress that have led to a better understanding of this complex protein, and outline the questions that have yet to be answered.

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Ye Zhou, Scott A Ness. Myb proteins: angels and demons in normal and transformed cells. Frontiers in Bioscience-Landmark. 2011. 16(3); 1109-1131.