Open Access
Tight junctions in cancer metastasis
Tracey A Martin1,Malcolm D Mason1,Wen G Jiang1
Metastasis and Angiogenesis Research Group, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
DOI: 10.2741/3726 Volume 16 Issue 3, pp.898-936
Published: 01 January 2011
(This article belongs to the Special Issue Bone metastasis, the molecular, cellular and clinical prospects)

Tight Junctions (TJ) are well known to function as a control for the paracellular diffusion of ions and certain molecules, it has however, become evident that the TJ has a vital role in maintaining cell to cell integrity. Loss of cohesion of the TJ structure can lead to invasion and ultimately to the metastasis of cancer cells. This review will discuss how modulation of expression of TJ molecules results in key changes in TJ barrier function leading to the progression of cancer and progression of metastasis.

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Tracey A Martin, Malcolm D Mason, Wen G Jiang. Tight junctions in cancer metastasis. Frontiers in Bioscience-Landmark. 2011. 16(3); 898-936.