Open Access
Article
Regulation of VSMC behavior by the cadherin-catenin complex
Cressida Lyon1,Carina Mill1,Aikaterini Tsaousi1,Helen Williams1,Sarah George1
1
Bristol Heart Institute, University of Bristol, Research Floor Level Seven, Bristol Royal Infirmary, Upper Maudlin St, Bristol BS2 8HW, United Kingdom
DOI: 10.2741/3711 Volume 16 Issue 2, pp.644-657
Published: 01 January 2011
(This article belongs to the Special Issue Signalling pathways in cardiovascular function and diseases)
Abstract

Vascular smooth muscle cells (VSMCs) are the predominant cell type within blood vessels. In normal vessels VSMC have low rates of proliferation, migration and apoptosis. However, increased VSMC proliferation, migration, and apoptosis rates radically alter the composition and structure of the blood vessel wall and contribute to vascular diseases such as atherosclerosis, in-stent restenosis and vein graft failure. Consequently, therapies that modulate VSMC proliferation, migration and apoptosis may be useful for treating vascular diseases. In this review article we discuss recently emerging research that has revealed that homophilic cell-cell contacts mediated by the cadherin:catenin complex and Wnt/beta-catenin signalling are important regulators of VSMC behaviour.

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Cressida Lyon, Carina Mill, Aikaterini Tsaousi, Helen Williams, Sarah George. Regulation of VSMC behavior by the cadherin-catenin complex. Frontiers in Bioscience-Landmark. 2011. 16(2); 644-657.