Open Access
Modulation of programmed cell death pathways by the hepatitis C virus
Jude Juventus Aweya1,Yee-Joo Tan1
Collaborative Anti-Viral Research Group, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore
DOI: 10.2741/3709 Volume 16 Issue 2, pp.608-618
Published: 01 January 2011
(This article belongs to the Special Issue Molecular bases and therapeutic options of hepatitis viruses)

Hepatitis C virus (HCV), a positive stranded RNA virus of the family Flaviviridae, is the major cause of non-A, non-B hepatitis worldwide. The HCV genome encodes a precursor polyprotein of ~ 3,000 amino acids that is processed co-translationally and post-translationally to give rise to viral structural and non-structural proteins. Nearly all of these viral proteins have been shown to modulate cell death via various mechanisms. In addition, studies using the replicon and recombinant HCV cell culture systems have yield important insights into the modulation of programmed cell death by HCV replication. Here, we summarize current knowledge on the modulation of apoptosis and other programmed cell death pathways by the HCV in these cell culture systems.

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Jude Juventus Aweya, Yee-Joo Tan. Modulation of programmed cell death pathways by the hepatitis C virus. Frontiers in Bioscience-Landmark. 2011. 16(2); 608-618.