Open Access
Article
Functional role of Akt in macrophage-mediated innate immunity
Yong Gyu Lee1,Jaehwi Lee1,Se Eun Byeon1,Dae Sung Yoo1,Min Ho Kim1,Song Yi Lee1,Jae Youl Cho1
1
College of Biomedical Science, and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea
DOI: 10.2741/3702 Volume 16 Issue 2, pp.517-530
Published: 01 January 2011
(This article belongs to the Special Issue Signaling in cancer and disease)
Abstract

Akt (protein kinase B) is a serine/threonine protein kinase that regulates cell metabolism, survival and proliferation. Recent studies of the role of Akt in phagocytosis, intracellular bacterial infections, LPS tolerance, production of inflammatory cytokines and mediators, and migration during macrophage-mediated innate immunity strongly suggest a pivotal role for this enzyme in the functional activation of macrophages. Considering that a variety of inflammatory diseases, such as rheumatoid arthritis, atherosclerosis, diabetes, obesity, cancer and osteoporosis, are regulated by macrophage-mediated innate immunity, efforts should be more carefully focused on understanding the function of Akt in macrophage-mediated innate immunity. Although few studies have addressed this question, this review discusses recent findings that support an important role for Akt in macrophage-mediated innate immunity and underlines the need for trials to develop pharmaceutically useful drugs that target Akt for treatment of macrophage-mediated inflammatory diseases. The findings we review here suggest that a novel and safe Akt inhibitor with strong immunosuppressive and anti-inflammatory properties will be applied to various chronic inflammatory diseases in the near future.

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Yong Gyu Lee, Jaehwi Lee, Se Eun Byeon, Dae Sung Yoo, Min Ho Kim, Song Yi Lee, Jae Youl Cho. Functional role of Akt in macrophage-mediated innate immunity. Frontiers in Bioscience-Landmark. 2011. 16(2); 517-530.